September 22, 2016
Your skin is a critically important organ. It’s also very sensitive. So how do the makers of skin care products ensure they aren’t inadvertently damaging the skin of their customers each time they introduce a new formulation?
For many years, the answer has been to test chemicals on animals before they are released for sale to humans. Yet animal testing is a controversial process that many find repugnant.
That’s why it’s good to learn of a new skin sensitization test that could do away with clinical trials on animals. Kao and Shiseido have developed a technique that enables substances to be tested in vitro, using human immune cells.
h-CLAT" is an alternative method for evaluating the skin sensitization to chemicals in an accurate and prompt manner with lower cost based on the system in which two types of proteins (CD86*3 and CD54*4 ) increase on the cell surface of the human acute monocytic leukemia cell line, THP-1.
With Europe prohibiting all animal testing for cosmetic products, we can expect further development of sophisticated in-vitro tests to ensure the safety of skin care products.
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